Assay Detail
Binding
CHEMBL944465
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Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor expressed in HKRK-B28 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HKRK-B28 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Parathyroid hormone/parathyroid hormone-related peptide receptor (CHEMBL1793) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.42 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506126 | — | — | 1 | 8.16 |
| CHEMBL526530 | — | — | 1 | 8.14 |
| CHEMBL526677 | — | — | 1 | 7.87 |
| CHEMBL525069 | — | — | 1 | 7.01 |
| CHEMBL515170 | — | — | 1 | 6.00 |
| CHEMBL499651 | — | — | 1 | 5.66 |
| CHEMBL505612 | — | — | 1 | 4.99 |
| CHEMBL514849 | — | — | 1 | 4.98 |
| CHEMBL450474 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506126 | — | IC50 | = | 6.87 | nM | 8.16 |
| CHEMBL526530 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL526677 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL525069 | — | IC50 | = | 98.2 | nM | 7.01 |
| CHEMBL515170 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL499651 | — | IC50 | = | 2187.0 | nM | 5.66 |
| CHEMBL505612 | — | IC50 | = | 10130.0 | nM | 4.99 |
| CHEMBL514849 | — | IC50 | = | 10484.0 | nM | 4.98 |
| CHEMBL450474 | — | IC50 | = | 10560.0 | nM | 4.98 |