Assay Detail
Functional
CHEMBL944463
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at rat PTH/PTH-related peptide receptor expressed in rat UMR106 cells assessed as cAMP formation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | UMR106 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Parathyroid hormone/parathyroid hormone-related peptide receptor (CHEMBL6038) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.14 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506126 | — | — | 1 | 8.96 |
| CHEMBL499651 | — | — | 1 | 6.89 |
| CHEMBL514849 | — | — | 1 | 6.81 |
| CHEMBL505612 | — | — | 1 | 6.60 |
| CHEMBL450474 | — | — | 1 | 6.46 |
| CHEMBL526677 | — | — | 1 | - |
| CHEMBL525069 | — | — | 1 | - |
| CHEMBL526530 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506126 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL499651 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL514849 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL505612 | — | EC50 | = | 251.0 | nM | 6.60 |
| CHEMBL450474 | — | EC50 | = | 344.0 | nM | 6.46 |
| CHEMBL526677 | — | EC50 | - | — | - | |
| CHEMBL525069 | — | EC50 | - | — | - | |
| CHEMBL526530 | — | EC50 | - | — | - |