Review anchor
Parathyroid hormone/parathyroid hormone-related peptide receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
Evidence Snapshot
Parathyroid hormone/parathyroid hormone-related peptide receptor
CHEMBL6038
SINGLE PROTEIN
Rattus norvegicus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Parathyroid hormone/parathyroid hormone-related peptide receptor as ChEMBL target CHEMBL6038, mapped to UniProt P25961. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL6038
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P25961
Parathyroid hormone/parathyroid hormone-related peptide receptor
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Parathyroid hormone/parathyroid hormone-related peptide receptor matters
Parathyroid hormone/parathyroid hormone-related peptide receptor is reviewed as Parathyroid hormone/parathyroid hormone-related peptide receptor (UniProt P25961); the current evidence base includes 0 approved drugs, 14 compounds, and 3 assays, with lead potency reaching pChEMBL 9.0.
Protein context
Parathyroid hormone/parathyroid hormone-related peptide receptor
Parathyroid hormone/parathyroid hormone-related peptide receptor Sequence length is 591 aa.
Review this target as Parathyroid hormone/parathyroid hormone-related peptide receptor, mapped to UniProt P25961. Sequence length is 591 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P25961
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 0 approved drugs, 14 compounds, and 3 assays for this target. The dominant activity type is EC50. CHEMBL506126 is the current potency anchor at pChEMBL 9.0.
Use CHEMBL506126 as the tractability anchor when discussing potency (pChEMBL 9.0).
Activity source · ChEMBL 36 via Core Engine
pChEMBL 9.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Parathyroid hormone/parathyroid hormone-related peptide receptor matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P25961, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
14
Total Compounds
3
Total Assays
0
Approved Drugs
EC50: 13.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL506126
|
9.0 | EC50 | — |
|
|
No preferred name
CHEMBL499651
|
6.9 | EC50 | — |
|
|
No preferred name
CHEMBL514849
|
6.8 | EC50 | — |
|
|
No preferred name
CHEMBL505612
|
6.6 | EC50 | — |
|
|
No preferred name
CHEMBL450474
|
6.5 | EC50 | — |
Source Header