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Target Snapshot

CHEMBL6038 Target Snapshot

Parathyroid hormone/parathyroid hormone-related peptide receptor · SINGLE PROTEIN · Rattus norvegicus

14Compounds
3Assays
0Approved Drugs
13.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P25961. Use UniProt P25961 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P25961 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Parathyroid hormone/parathyroid hormone-related peptide receptor as ChEMBL target CHEMBL6038, mapped to UniProt P25961. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Parathyroid hormone/parathyroid hormone-related peptide receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL6038
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P25961
Parathyroid hormone/parathyroid hormone-related peptide receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Parathyroid hormone/parathyroid hormone-related peptide receptor is the right protein anchor across sources, using UniProt P25961 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelParathyroid hormone/parathyroid hormone-related peptide receptor
UniProt AccessionP25961
Component TypeProtein
Sequence Length591 aa

Parathyroid hormone/parathyroid hormone-related peptide receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Parathyroid hormone/parathyroid hormone-related peptide receptor, mapped to UniProt P25961. Sequence length is 591 aa.

Mapped IDP25961
Review nameParathyroid hormone/parathyroid hormone-related peptide receptor
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Phase I
Assay Mix

Activity Type Distribution

EC5013.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL506126 8.96 EC50 1.1 Preclinical
CHEMBL499651 6.89 EC50 129.0 Preclinical
CHEMBL514849 6.81 EC50 155.0 Preclinical
CHEMBL505612 6.6 EC50 251.0 Preclinical
CHEMBL450474 6.46 EC50 344.0 Preclinical
CHEMBL3962850 5.72 EC50 1900.0 Preclinical
CHEMBL3959465 5.64 EC50 2300.0 Preclinical
CHEMBL3976807 5.62 EC50 2400.0 Preclinical
CHEMBL3916272 5.5 EC50 3200.0 Preclinical
CHEMBL3964997 4.92 EC50 12000.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
4
5.5
1
6.0
3
6.5
0
7.0
0
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

3
Total Assays
10
Tested Compounds
1
Assay Types
Functional — 3 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 10 6.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine