Assay Detail
Functional
CHEMBL944654
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Antiviral activity against HIV1 LAI infected in human CEM-SS cells assessed as reverse transcriptase activity after 5 days by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and in vitro biological evaluation of valine-containing prodrugs derived from clinically used HIV-protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.07 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 8.70 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 8.05 |
| CHEMBL445706 | — | — | 1 | 7.77 |
| CHEMBL505494 | — | — | 1 | 7.44 |
| CHEMBL506295 | — | — | 1 | 7.05 |
| CHEMBL503493 | — | — | 1 | 7.03 |
| CHEMBL501570 | — | — | 1 | 6.85 |
| CHEMBL504646 | — | — | 1 | 6.76 |
| CHEMBL447877 | — | — | 1 | 6.19 |
| CHEMBL508351 | — | — | 1 | 4.81 |
| CHEMBL1735 | INDINAVIR SULFATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL584 | NELFINAVIR | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL445706 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL505494 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL506295 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL503493 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL501570 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL504646 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL447877 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL508351 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL1735 | INDINAVIR SULFATE | IC50 | <= | 10.0 | nM | - |