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Assay Detail

CHEMBL944754

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Binding
Inhibition of MMP9
43
Total Activities
43
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Matrix metalloproteinase-9 (CHEMBL321)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 2. Optimization of alpha-amino substituents.
Yang SM, Scannevin RH, Wang B, Burke SL, Huang Z, Karnachi P, Wilson LJ, Rhodes KJ, Lagu B, Murray WV.
Bioorg Med Chem Lett (2008) 18 : 1140 -1145
PubMed 18083558 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 41 8.34 9.34
Ki 2 9.10 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL400285 1 9.34
CHEMBL254293 1 9.28
CHEMBL253032 1 9.28
CHEMBL400785 1 9.27
CHEMBL401404 1 9.21
CHEMBL251831 1 9.17
CHEMBL180616 1 9.15
CHEMBL254506 1 9.05
CHEMBL103418 1 9.05
CHEMBL399029 1 8.96
CHEMBL399565 1 8.89
CHEMBL253033 1 8.89
CHEMBL400784 1 8.82
CHEMBL429123 1 8.77
CHEMBL398351 1 8.77
CHEMBL253242 1 8.74
CHEMBL398644 1 8.72
CHEMBL398265 1 8.72
CHEMBL254929 1 8.70
CHEMBL253892 1 8.64
CHEMBL252827 1 8.62
CHEMBL254509 1 8.60
CHEMBL253450 1 8.55
CHEMBL400641 1 8.54
CHEMBL429486 1 8.49
CHEMBL398331 1 8.33
CHEMBL430210 1 8.32
CHEMBL252022 1 8.27
CHEMBL400193 1 8.15
CHEMBL252422 1 8.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL400285 IC50 = 0.46 nM 9.34
CHEMBL254293 IC50 = 0.52 nM 9.28
CHEMBL253032 IC50 = 0.52 nM 9.28
CHEMBL400785 IC50 = 0.54 nM 9.27
CHEMBL401404 IC50 = 0.62 nM 9.21
CHEMBL251831 IC50 = 0.68 nM 9.17
CHEMBL180616 Ki = 0.7 nM 9.15
CHEMBL254506 IC50 = 0.89 nM 9.05
CHEMBL103418 Ki = 0.9 nM 9.05
CHEMBL399029 IC50 = 1.1 nM 8.96
CHEMBL399565 IC50 = 1.3 nM 8.89
CHEMBL253033 IC50 = 1.3 nM 8.89
CHEMBL400784 IC50 = 1.5 nM 8.82
CHEMBL429123 IC50 = 1.7 nM 8.77
CHEMBL398351 IC50 = 1.7 nM 8.77
CHEMBL253242 IC50 = 1.8 nM 8.74
CHEMBL398644 IC50 = 1.9 nM 8.72
CHEMBL398265 IC50 = 1.9 nM 8.72
CHEMBL254929 IC50 = 2.0 nM 8.70
CHEMBL253892 IC50 = 2.3 nM 8.64
CHEMBL252827 IC50 = 2.4 nM 8.62
CHEMBL254509 IC50 = 2.5 nM 8.60
CHEMBL253450 IC50 = 2.8 nM 8.55
CHEMBL400641 IC50 = 2.9 nM 8.54
CHEMBL429486 IC50 = 3.2 nM 8.49
CHEMBL398331 IC50 = 4.7 nM 8.33
CHEMBL430210 IC50 = 4.8 nM 8.32
CHEMBL252022 IC50 = 5.4 nM 8.27
CHEMBL400193 IC50 = 7.1 nM 8.15
CHEMBL252422 IC50 = 7.8 nM 8.11
CHEMBL252426 IC50 = 8.8 nM 8.06
CHEMBL252826 IC50 = 14.0 nM 7.85
CHEMBL428591 IC50 = 17.0 nM 7.77
CHEMBL399566 IC50 = 20.0 nM 7.70
CHEMBL400192 IC50 = 23.0 nM 7.64
CHEMBL252823 IC50 = 29.0 nM 7.54
CHEMBL398350 IC50 = 31.0 nM 7.51
CHEMBL400445 IC50 = 68.0 nM 7.17
CHEMBL251821 IC50 = 86.0 nM 7.07
CHEMBL252021 IC50 = 121.0 nM 6.92
CHEMBL254718 IC50 = 256.0 nM 6.59
CHEMBL251827 IC50 = 295.0 nM 6.53
CHEMBL252020 IC50 > 10000.0 nM -