Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL944977

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]BH-CCK-8S from CC1 receptor expressed in guinea pig pancreatic cells
21
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Cholecystokinin receptor type A (CHEMBL3501)
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

Rationalizing the activities of diverse cholecystokinin 2 receptor antagonists using molecular field points.
Low CM, Vinter JG.
J Med Chem (2008) 51 : 565 -573
PubMed 18201065 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 5.78 7.20
Log Ki 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL401098 1 7.20
CHEMBL398312 1 6.50
CHEMBL9387 L-365260 1 6.50
CHEMBL324547 NETAZEPIDE 2.0 1 6.40
CHEMBL390519 1 6.30
CHEMBL2062154 CI-988 1.0 1 6.20
CHEMBL301810 1 6.10
CHEMBL252150 1 6.10
CHEMBL252559 1 5.90
CHEMBL254020 1 5.70
CHEMBL342616 1 5.70
CHEMBL401097 1 5.60
CHEMBL400974 1 5.60
CHEMBL399252 1 5.50
CHEMBL14557 1 5.40
CHEMBL14571 1 5.40
CHEMBL278032 1 5.10
CHEMBL118930 1 5.10
CHEMBL117281 1 4.70
CHEMBL400548 1 4.60
CHEMBL301095 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL401098 Ki = 63.1 nM 7.20
CHEMBL398312 Ki = 316.23 nM 6.50
CHEMBL9387 L-365260 Ki = 316.23 nM 6.50
CHEMBL324547 NETAZEPIDE Ki = 398.11 nM 6.40
CHEMBL390519 Ki = 501.19 nM 6.30
CHEMBL2062154 CI-988 Ki = 630.96 nM 6.20
CHEMBL301810 Ki = 794.33 nM 6.10
CHEMBL252150 Ki = 794.33 nM 6.10
CHEMBL252559 Ki = 1258.93 nM 5.90
CHEMBL254020 Ki = 1995.26 nM 5.70
CHEMBL342616 Ki = 1995.26 nM 5.70
CHEMBL401097 Ki = 2511.89 nM 5.60
CHEMBL400974 Ki = 2511.89 nM 5.60
CHEMBL399252 Ki = 3162.28 nM 5.50
CHEMBL14557 Ki = 3981.07 nM 5.40
CHEMBL14571 Ki = 3981.07 nM 5.40
CHEMBL278032 Ki = 7943.28 nM 5.10
CHEMBL118930 Ki = 7943.28 nM 5.10
CHEMBL117281 Ki = 19952.62 nM 4.70
CHEMBL400548 Ki = 25118.86 nM 4.60
CHEMBL301095 Log Ki - -