Assay Detail
Binding
CHEMBL944978
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Inhibition of human Cdc7
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Cell division cycle 7-related protein kinase (CHEMBL5443) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 7.25 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399492 | — | — | 1 | 8.70 |
| CHEMBL250062 | — | — | 1 | 8.52 |
| CHEMBL253768 | — | — | 1 | 8.40 |
| CHEMBL250061 | — | — | 1 | 8.40 |
| CHEMBL430021 | — | — | 1 | 8.30 |
| CHEMBL402272 | — | — | 1 | 8.15 |
| CHEMBL401396 | — | — | 1 | 8.15 |
| CHEMBL248853 | — | — | 1 | 8.10 |
| CHEMBL253545 | — | — | 1 | 8.05 |
| CHEMBL225519 | — | — | 1 | 8.00 |
| CHEMBL398627 | — | — | 1 | 7.92 |
| CHEMBL400270 | — | — | 1 | 7.89 |
| CHEMBL253760 | — | — | 1 | 7.85 |
| CHEMBL398833 | — | — | 1 | 7.85 |
| CHEMBL1203954 | — | — | 1 | 7.70 |
| CHEMBL251247 | — | — | 1 | 7.64 |
| CHEMBL250693 | — | — | 1 | 7.57 |
| CHEMBL254597 | — | — | 1 | 7.55 |
| CHEMBL251246 | — | — | 1 | 7.38 |
| CHEMBL398261 | — | — | 1 | 7.35 |
| CHEMBL400271 | — | — | 1 | 7.33 |
| CHEMBL250870 | — | — | 1 | 7.17 |
| CHEMBL398626 | — | — | 1 | 7.06 |
| CHEMBL400475 | — | — | 1 | 6.92 |
| CHEMBL250884 | — | — | 1 | 6.86 |
| CHEMBL226232 | — | — | 1 | 6.83 |
| CHEMBL248174 | — | — | 1 | 6.80 |
| CHEMBL250869 | — | — | 1 | 6.80 |
| CHEMBL254390 | — | — | 1 | 6.75 |
| CHEMBL250692 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399492 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL250062 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL250061 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL253768 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL430021 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL402272 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL401396 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL248853 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL253545 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL225519 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL398627 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL400270 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL398833 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL253760 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1203954 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL251247 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL250693 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL254597 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL251246 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL398261 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL400271 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL250870 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL398626 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL400475 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL250884 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL226232 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL248174 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL250869 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL254390 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL250692 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL250691 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL249254 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL251283 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL400596 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL251282 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL250453 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL252724 | — | IC50 | = | 404.0 | nM | 6.39 |
| CHEMBL251469 | — | IC50 | = | 636.0 | nM | 6.20 |
| CHEMBL251472 | — | IC50 | = | 655.0 | nM | 6.18 |
| CHEMBL398521 | — | IC50 | = | 863.0 | nM | 6.06 |
| CHEMBL249646 | — | IC50 | = | 1397.0 | nM | 5.86 |
| CHEMBL250871 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL253980 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL398560 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL251281 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL254596 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL254392 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL255031 | — | IC50 | > | 5000.0 | nM | - |