Assay Detail
Functional
CHEMBL945015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-stimulated TNFalpha release in human whole blood
28
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 8-biarylquinolines: a novel class of PDE4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.25 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252490 | — | — | 1 | 7.10 |
| CHEMBL251882 | — | — | 1 | 6.92 |
| CHEMBL252491 | — | — | 1 | 6.92 |
| CHEMBL252089 | — | — | 1 | 6.82 |
| CHEMBL372575 | — | — | 1 | 6.80 |
| CHEMBL252687 | — | — | 1 | 6.62 |
| CHEMBL252469 | — | — | 1 | 6.51 |
| CHEMBL254518 | — | — | 1 | 6.50 |
| CHEMBL252887 | — | — | 1 | 6.48 |
| CHEMBL403065 | — | — | 1 | 6.40 |
| CHEMBL403546 | — | — | 1 | 6.37 |
| CHEMBL252090 | — | — | 1 | 6.32 |
| CHEMBL436847 | — | — | 1 | 6.32 |
| CHEMBL403977 | — | — | 1 | 6.28 |
| CHEMBL252287 | — | — | 1 | 6.25 |
| CHEMBL251883 | — | — | 1 | 6.24 |
| CHEMBL402953 | — | — | 1 | 6.22 |
| CHEMBL253083 | — | — | 2 | 6.22 |
| CHEMBL401663 | — | — | 1 | 6.16 |
| CHEMBL252685 | — | — | 1 | 6.09 |
| CHEMBL252686 | — | — | 1 | 6.07 |
| CHEMBL252886 | — | — | 1 | 6.04 |
| CHEMBL253082 | — | — | 1 | 6.03 |
| CHEMBL252088 | — | — | 1 | 5.96 |
| CHEMBL403744 | — | — | 1 | 5.75 |
| CHEMBL252489 | — | — | 1 | 5.20 |
| CHEMBL252885 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252490 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL252491 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL251882 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL252089 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL372575 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL252687 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL252469 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL254518 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL252887 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL403065 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL403546 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL436847 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL252090 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL403977 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL252287 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL251883 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL253083 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL402953 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL401663 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL252685 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL252686 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL252886 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL253082 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL252088 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL253083 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL403744 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL252489 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL252885 | — | IC50 | = | 25000.0 | nM | 4.60 |