Assay Detail
Binding
CHEMBL945053
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Displacement of [125I](Leu8,D-Trp22,Tyr25)-SRIF28 from human sst5 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel sst5-selective somatostatin dicarba-analogues: synthesis and conformation-affinity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.40 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442494 | — | — | 1 | 8.68 |
| CHEMBL252355 | — | — | 1 | 7.55 |
| CHEMBL267054 | — | — | 1 | 6.69 |
| CHEMBL254210 | — | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442494 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL252355 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL267054 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL254210 | — | IC50 | = | 206.0 | nM | 6.69 |