Compound Detail

CHEMBL254210

Enter ChEMBL ID:

Free Research Context This compound will appear in recent viewed items on the research home for this browser.

C[C@@H](O)[C@@H](CO)NC(=O)[C@@H]1C/C=C\C[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL254210
Phase	Preclinical
Structure Type	MOL
InChI Key	VVRYKLAVRKNGHY-VUBFVVBWSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

1027.2

MW (Da)

Drug Information

Molecule Type	Small molecule
Availability	Unknown
Chirality	Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula	C56H70N10O9
MW	1027.24

Activity Summary

IC50 3 meas. best 6.85

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Somatostatin receptor type 4 CHEMBL1853	IC50	6.85	6.85	141.0	1
Somatostatin receptor type 5 CHEMBL1792	IC50	6.69	6.69	206.0	1
Somatostatin receptor type 1 CHEMBL1917	IC50	6.02	6.02	961.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Somatostatin receptor type 4	IC50	=	141.0	nM	6.85	Displacement of [125I](Leu8,D-Trp22,Tyr25)-SRIF28 from human sst4 receptor	18210999
Somatostatin receptor type 5	IC50	=	206.0	nM	6.69	Displacement of [125I](Leu8,D-Trp22,Tyr25)-SRIF28 from human sst5 receptor	18210999
Somatostatin receptor type 1	IC50	=	961.0	nM	6.02	Displacement of [125I](Leu8,D-Trp22,Tyr25)-SRIF28 from human sst1 receptor	18210999

Literature References

PubMed	DOI	Target Context	# Activities
18210999	10.1021/jm070886i	Somatostatin receptor type 1	1
18210999	10.1021/jm070886i	Somatostatin receptor type 2	1
18210999	10.1021/jm070886i	Somatostatin receptor type 3	1
18210999	10.1021/jm070886i	Somatostatin receptor type 4	1
18210999	10.1021/jm070886i	Somatostatin receptor type 5	1

Data from ChEMBL 36 via Core Engine