Assay Detail
Binding
CHEMBL945079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of humanized rabbit cathepsin K
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 9.11 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437501 | — | — | 1 | 9.70 |
| CHEMBL481611 | ODANACATIB | 3.0 | 1 | 9.70 |
| CHEMBL399733 | — | — | 1 | 9.70 |
| CHEMBL398910 | — | — | 1 | 9.52 |
| CHEMBL252383 | — | — | 1 | 9.52 |
| CHEMBL252571 | — | — | 1 | 9.40 |
| CHEMBL203665 | RELACATIB | 2.0 | 1 | 9.30 |
| CHEMBL399361 | — | — | 1 | 9.22 |
| CHEMBL252179 | — | — | 1 | 9.22 |
| CHEMBL250294 | — | — | 1 | 8.92 |
| CHEMBL252784 | — | — | 1 | 8.82 |
| CHEMBL428417 | — | — | 1 | 8.40 |
| CHEMBL252382 | — | — | 1 | 8.29 |
| CHEMBL252581 | — | — | 1 | 7.80 |
| CHEMBL252582 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437501 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL481611 | ODANACATIB | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL399733 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL398910 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL252383 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL252571 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL203665 | RELACATIB | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL399361 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL252179 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL250294 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL252784 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL428417 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL252382 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL252581 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL252582 | — | IC50 | < | 0.2 | nM | - |