Assay Detail
Binding
CHEMBL945082
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Inhibition of cathepsin S
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.78 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252582 | — | — | 1 | 7.82 |
| CHEMBL399733 | — | — | 1 | 7.77 |
| CHEMBL399361 | — | — | 1 | 7.42 |
| CHEMBL398910 | — | — | 1 | 7.25 |
| CHEMBL481611 | ODANACATIB | 3.0 | 1 | 7.22 |
| CHEMBL252784 | — | — | 1 | 7.05 |
| CHEMBL252571 | — | — | 1 | 6.77 |
| CHEMBL437501 | — | — | 1 | 6.75 |
| CHEMBL252179 | — | — | 1 | 6.66 |
| CHEMBL252383 | — | — | 1 | 6.58 |
| CHEMBL250294 | — | — | 1 | 5.65 |
| CHEMBL428417 | — | — | 1 | 5.60 |
| CHEMBL252382 | — | — | 1 | 5.55 |
| CHEMBL252581 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252582 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL399733 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL399361 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL398910 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL481611 | ODANACATIB | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL252784 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL252571 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL437501 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL252179 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL252383 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL250294 | — | IC50 | = | 2237.0 | nM | 5.65 |
| CHEMBL428417 | — | IC50 | = | 2489.0 | nM | 5.60 |
| CHEMBL252382 | — | IC50 | = | 2834.0 | nM | 5.55 |
| CHEMBL252581 | — | IC50 | > | 10000.0 | nM | - |