Assay Detail

CHEMBL945084

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Binding

Inhibition of cathepsin V

ChEMBL ↗

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Target

Cathepsin L2 (CHEMBL3272) ↗

Open DB target context

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Cathepsin L2 (CHEMBL3272) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cathepsin L2

CHEMBL3272

Anchored from Assay target.

Protein identity Cathepsin L2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Intermediate

Target

Cathepsin L2 (CHEMBL3272) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

Gauthier JY, Chauret N, Cromlish W, Desmarais S, Duong LT, Falgueyret JP, Kimmel DB, Lamontagne S, Léger S, LeRiche T, Li CS, Massé F, McKay DJ, Nicoll-Griffith DA, Oballa RM, Palmer JT, Percival MD, Riendeau D, Robichaud J, Rodan GA, Rodan SB, Seto C, Thérien M, Truong VL, Venuti MC, Wesolowski G, Young RN, Zamboni R, Black WC.
Bioorg Med Chem Lett (2008) 18 : 923 -928
PubMed 18226527 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.12	6.12

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL481611	ODANACATIB	3.0	1	6.12

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL481611	ODANACATIB	IC50	=	762.0	nM	6.12