Assay Detail
Binding
CHEMBL945135
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pig TACE
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3332) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.00 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401263 | — | — | 1 | 9.00 |
| CHEMBL251994 | — | — | 1 | 9.00 |
| CHEMBL401471 | — | — | 1 | 9.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401263 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL251994 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL401471 | — | IC50 | = | 1.0 | nM | 9.00 |