Assay Detail
Functional
CHEMBL945136
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Inhibition of LPS-induced TNFalpha production in human whole blood
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.14 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401263 | — | — | 1 | 7.62 |
| CHEMBL401471 | — | — | 1 | 6.97 |
| CHEMBL251994 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401263 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL401471 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL251994 | — | IC50 | = | 143.0 | nM | 6.84 |