Assay Detail
Binding
CHEMBL945288
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membrane by liquid scintillation counting
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.03 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129530 | — | — | 1 | 7.67 |
| CHEMBL516814 | — | — | 1 | 7.67 |
| CHEMBL20730 | VESAMICOL | — | 1 | 7.59 |
| CHEMBL461956 | — | — | 1 | 7.51 |
| CHEMBL473129 | — | — | 3 | 6.73 |
| CHEMBL473546 | — | — | 1 | 6.66 |
| CHEMBL473547 | — | — | 1 | 6.53 |
| CHEMBL473751 | — | — | 1 | - |
| CHEMBL473548 | — | — | 1 | - |
| CHEMBL87379 | BENZOVESAMICOL | — | 1 | - |
| CHEMBL461783 | — | — | 1 | - |
| CHEMBL510679 | — | — | 1 | - |
| CHEMBL462659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129530 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL516814 | — | Ki | = | 21.3 | nM | 7.67 |
| CHEMBL20730 | VESAMICOL | Ki | = | 25.8 | nM | 7.59 |
| CHEMBL461956 | — | Ki | = | 30.6 | nM | 7.51 |
| CHEMBL473129 | — | Ki | = | 185.97 | nM | 6.73 |
| CHEMBL473129 | — | Ki | = | 191.1 | nM | 6.72 |
| CHEMBL473546 | — | Ki | = | 219.6 | nM | 6.66 |
| CHEMBL473547 | — | Ki | = | 297.7 | nM | 6.53 |
| CHEMBL473129 | — | Ki | = | 658.6 | nM | 6.18 |
| CHEMBL473751 | — | Ki | - | — | - | |
| CHEMBL473548 | — | Ki | - | — | - | |
| CHEMBL87379 | BENZOVESAMICOL | Ki | - | — | - | |
| CHEMBL461783 | — | Ki | - | — | - | |
| CHEMBL510679 | — | Ki | - | — | - | |
| CHEMBL462659 | — | Ki | - | — | - |