Assay Detail
Functional
CHEMBL945391
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Inverse agonist activity at human H3 receptor expressed in CHOK1 cells by GTPgammaS binding assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel H3 receptor antagonists with improved pharmacokinetic profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.70 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408934 | — | — | 1 | 9.00 |
| CHEMBL471555 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408934 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL471555 | — | Ki | = | 4.0 | nM | 8.40 |