Assay Detail
Functional
CHEMBL945468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Stat3 DNA binding activity in EGF-stimulated mouse NIH3T3 cells expressing hEGFR with activated Stat1, Stat3, Stat5
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.07 | 4.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477936 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477936 | — | IC50 | = | 86000.0 | nM | 4.07 |