Assay Detail
Binding
CHEMBL945751
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Displacement of [125I] eotaxin from human CCR3 receptor in CHO cells
38
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part II: Acyclic replacements for the (3S)-3-benzylpiperidine in a series of potent CCR3 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 8.57 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254095 | — | — | 1 | 9.70 |
| CHEMBL398548 | — | — | 1 | 9.70 |
| CHEMBL251837 | — | — | 1 | 9.70 |
| CHEMBL399495 | — | — | 1 | 9.52 |
| CHEMBL252035 | — | — | 1 | 9.52 |
| CHEMBL437396 | — | — | 1 | 9.52 |
| CHEMBL252631 | — | — | 1 | 9.40 |
| CHEMBL428062 | — | — | 2 | 9.40 |
| CHEMBL400378 | — | — | 1 | 9.40 |
| CHEMBL251838 | — | — | 1 | 9.40 |
| CHEMBL254503 | — | — | 1 | 9.40 |
| CHEMBL254676 | — | — | 1 | 9.30 |
| CHEMBL251822 | — | — | 1 | 9.30 |
| CHEMBL253210 | — | — | 1 | 9.22 |
| CHEMBL254881 | — | — | 1 | 9.22 |
| CHEMBL254677 | — | — | 1 | 9.22 |
| CHEMBL363840 | — | — | 1 | 9.00 |
| CHEMBL253244 | — | — | 1 | 8.92 |
| CHEMBL254930 | — | — | 1 | 8.74 |
| CHEMBL252792 | — | — | 1 | 8.60 |
| CHEMBL254093 | — | — | 1 | 8.60 |
| CHEMBL251839 | — | — | 1 | 8.60 |
| CHEMBL254470 | — | — | 1 | 8.49 |
| CHEMBL400467 | — | — | 1 | 8.47 |
| CHEMBL253209 | — | — | 1 | 8.43 |
| CHEMBL252222 | — | — | 1 | 8.24 |
| CHEMBL401002 | — | — | 1 | 8.22 |
| CHEMBL254471 | — | — | 1 | 8.05 |
| CHEMBL253034 | — | — | 1 | 7.72 |
| CHEMBL254055 | — | — | 1 | 7.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL398548 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL251837 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL254095 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL399495 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL252035 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL437396 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL428062 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL254503 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL251838 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL400378 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL428062 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL252631 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL251822 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL254676 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL253210 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL254677 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL254881 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL363840 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL253244 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL254930 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL251839 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL252792 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL254093 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL254470 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL400467 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL253209 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL252222 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL401002 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL254471 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL253034 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL254055 | — | IC50 | = | 21.6 | nM | 7.67 |
| CHEMBL252034 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL253211 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL253666 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL398344 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL252628 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL252610 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL252221 | — | IC50 | = | 577.0 | nM | 6.24 |