Assay Detail
Functional
CHEMBL945755
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Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part II: Acyclic replacements for the (3S)-3-benzylpiperidine in a series of potent CCR3 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.63 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363840 | — | — | 1 | 11.00 |
| CHEMBL254930 | — | — | 1 | 10.89 |
| CHEMBL399495 | — | — | 1 | 10.42 |
| CHEMBL253210 | — | — | 1 | 9.22 |
| CHEMBL437396 | — | — | 1 | 8.59 |
| CHEMBL254503 | — | — | 1 | 7.66 |
| CHEMBL254881 | — | — | 1 | - |
| CHEMBL428062 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363840 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL254930 | — | IC50 | = | 0.013 | nM | 10.89 |
| CHEMBL399495 | — | IC50 | = | 0.038 | nM | 10.42 |
| CHEMBL253210 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL437396 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL254503 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL254881 | — | IC50 | = | 0.005 | nM | - |
| CHEMBL428062 | — | IC50 | = | 0.004 | nM | - |