Assay Detail
Functional
CHEMBL945872
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Antiviral activity against HIV1 3B
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationships of novel HIV-1 protease inhibitors containing the 3-amino-2-chlorobenzoyl-allophenylnorstatine structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.77 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 8.70 |
| CHEMBL256934 | — | — | 1 | 8.40 |
| CHEMBL272025 | — | — | 1 | 8.22 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 8.15 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 8.10 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.80 |
| CHEMBL403526 | — | — | 1 | 7.77 |
| CHEMBL272797 | — | — | 1 | 7.75 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.72 |
| CHEMBL257257 | — | — | 1 | 7.70 |
| CHEMBL271391 | — | — | 1 | 7.70 |
| CHEMBL269904 | — | — | 1 | 7.68 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 7.64 |
| CHEMBL409007 | — | — | 1 | 7.62 |
| CHEMBL300891 | — | — | 1 | 7.58 |
| CHEMBL272796 | — | — | 1 | 7.44 |
| CHEMBL408620 | — | — | 1 | 7.40 |
| CHEMBL437457 | — | — | 1 | 7.20 |
| CHEMBL404154 | — | — | 1 | 7.11 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL163 | RITONAVIR | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL256934 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL272025 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL114 | SAQUINAVIR | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL403526 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL272797 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL257257 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL271391 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL269904 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5483011 | INDINAVIR | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL409007 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL300891 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL272796 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL408620 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL437457 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL404154 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1163 | ATAZANAVIR | EC50 | < | 4.0 | nM | - |