Assay Detail
Functional
CHEMBL945873
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B in presence of 50% human serum
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationships of novel HIV-1 protease inhibitors containing the 3-amino-2-chlorobenzoyl-allophenylnorstatine structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.28 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256934 | — | — | 1 | 8.22 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 8.10 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 8.05 |
| CHEMBL409007 | — | — | 1 | 7.85 |
| CHEMBL403526 | — | — | 1 | 7.70 |
| CHEMBL272025 | — | — | 1 | 7.46 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 7.39 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 7.30 |
| CHEMBL300891 | — | — | 1 | 7.28 |
| CHEMBL257257 | — | — | 1 | 7.18 |
| CHEMBL271391 | — | — | 1 | 7.11 |
| CHEMBL408620 | — | — | 1 | 7.10 |
| CHEMBL272797 | — | — | 1 | 7.06 |
| CHEMBL272796 | — | — | 1 | 7.06 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 7.06 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.02 |
| CHEMBL269904 | — | — | 1 | 6.86 |
| CHEMBL404154 | — | — | 1 | 6.78 |
| CHEMBL437457 | — | — | 1 | 6.57 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256934 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1163 | ATAZANAVIR | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL409007 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL403526 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL272025 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL163 | RITONAVIR | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL114 | SAQUINAVIR | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL300891 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL257257 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL271391 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL408620 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL272797 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL272796 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5483011 | INDINAVIR | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL269904 | — | EC50 | = | 138.0 | nM | 6.86 |
| CHEMBL404154 | — | EC50 | = | 165.0 | nM | 6.78 |
| CHEMBL437457 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 293.0 | nM | 6.53 |