Assay Detail
Functional
CHEMBL945935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-stimulated PGE2 production in human whole blood
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.93 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416146 | ETORICOXIB | 4.0 | 1 | 5.96 |
| CHEMBL412099 | — | — | 1 | 5.89 |
| CHEMBL180650 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416146 | ETORICOXIB | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL412099 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL180650 | — | IC50 | > | 40000.0 | nM | - |