Assay Detail
Functional
CHEMBL945967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B in MT2 cells after 5 days
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Tricyclic HIV integrase inhibitors: potent and orally bioavailable C5-aza analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.21 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254524 | — | — | 1 | 8.85 |
| CHEMBL254318 | — | — | 1 | 8.77 |
| CHEMBL402290 | — | — | 1 | 8.51 |
| CHEMBL209854 | — | — | 1 | 8.47 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 8.22 |
| CHEMBL254522 | — | — | 1 | 8.00 |
| CHEMBL254523 | — | — | 1 | 7.51 |
| CHEMBL254317 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254524 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL254318 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL402290 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL209854 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL254316 | RALTEGRAVIR | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL254522 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL254523 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL254317 | — | EC50 | = | 47.0 | nM | 7.33 |