Assay Detail
Functional
CHEMBL945968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV in MT2 cells in presence of 35 mg/mL human serum albumin
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Tricyclic HIV integrase inhibitors: potent and orally bioavailable C5-aza analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.68 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402290 | — | — | 1 | 8.08 |
| CHEMBL254318 | — | — | 1 | 7.94 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 7.80 |
| CHEMBL254524 | — | — | 1 | 7.31 |
| CHEMBL209854 | — | — | 1 | 7.27 |
| CHEMBL254523 | — | — | 1 | - |
| CHEMBL254522 | — | — | 1 | - |
| CHEMBL254317 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402290 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL254318 | — | EC50 | = | 11.4 | nM | 7.94 |
| CHEMBL254316 | RALTEGRAVIR | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL254524 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL209854 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL254523 | — | EC50 | - | — | - | |
| CHEMBL254522 | — | EC50 | - | — | - | |
| CHEMBL254317 | — | EC50 | - | — | - |