Assay Detail
Binding
CHEMBL945979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.68 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254927 | — | — | 1 | 11.00 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 9.10 |
| CHEMBL254919 | — | — | 1 | 8.82 |
| CHEMBL254926 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254927 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL254919 | — | IC50 | = | 1.52 | nM | 8.82 |
| CHEMBL254926 | — | IC50 | = | 1560.0 | nM | 5.81 |