Assay Detail

CHEMBL946029

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Decrease in oxytocin-induced uterine contractions in iv dosed non-pregnant Sprague-Dawley rat

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Rattus norvegicus (CHEMBL376) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Rattus norvegicus (CHEMBL376) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Rattus norvegicus

CHEMBL376

Anchored from Assay target.

Protein identity Rattus norvegicus

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Confidence	1 — Organism
Curated By	Intermediate

Target

Rattus norvegicus (CHEMBL376) ↗

Type	ORGANISM
Organism	Rattus norvegicus

Publication

The discovery of GSK221149A: a potent and selective oxytocin antagonist.

Liddle J, Allen MJ, Borthwick AD, Brooks DP, Davies DE, Edwards RM, Exall AM, Hamlett C, Irving WR, Mason AM, McCafferty GP, Nerozzi F, Peace S, Philp J, Pollard D, Pullen MA, Shabbir SS, Sollis SL, Westfall TD, Woollard PM, Wu C, Hickey DM.
Bioorg Med Chem Lett (2008) 18 : 90 -94
PubMed 18032036 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
ID50	1	-	-
IC50	1	6.75	6.75

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL429736	RETOSIBAN	3.0	2	6.75

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL429736	RETOSIBAN	IC50	=	180.0	nM	6.75
CHEMBL429736	RETOSIBAN	ID50	=	0.27	mg.kg-1	-