Assay Detail
Functional
CHEMBL946413
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on osteoclast formation in ddY mouse bone marrow cells co cultured with primary osteoclasts after 3 days
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Bone marrow cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation, and crystal structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 9.82 | 10.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2021484 | — | — | 1 | 10.46 |
| CHEMBL2021483 | — | — | 1 | 10.40 |
| CHEMBL472160 | — | — | 1 | 10.32 |
| CHEMBL514116 | — | — | 1 | 9.66 |
| CHEMBL459034 | — | — | 1 | 9.37 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2021484 | — | EC50 | = | 0.035 | nM | 10.46 |
| CHEMBL2021483 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL472160 | — | EC50 | = | 0.048 | nM | 10.32 |
| CHEMBL514116 | — | EC50 | = | 0.22 | nM | 9.66 |
| CHEMBL459034 | — | EC50 | = | 0.43 | nM | 9.37 |
| CHEMBL846 | CALCITRIOL | EC50 | = | 2.0 | nM | 8.70 |