Assay Detail
Binding
CHEMBL946416
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Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | B300-19 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.38 | 7.16 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487635 | — | — | 1 | 7.16 |
| CHEMBL508207 | — | — | 1 | 7.14 |
| CHEMBL510375 | — | — | 1 | 6.18 |
| CHEMBL488640 | — | — | 1 | 6.14 |
| CHEMBL529664 | — | — | 1 | 5.92 |
| CHEMBL470962 | — | — | 1 | 5.72 |
| CHEMBL509396 | — | — | 1 | - |
| CHEMBL515355 | — | — | 1 | - |
| CHEMBL459465 | — | — | 1 | - |
| CHEMBL459464 | — | — | 1 | - |
| CHEMBL516936 | — | — | 1 | - |
| CHEMBL459463 | — | — | 1 | - |
| CHEMBL451783 | — | — | 1 | - |
| CHEMBL453594 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487635 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL508207 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL510375 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL488640 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL529664 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL470962 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL509396 | — | IC50 | - | — | - | |
| CHEMBL515355 | — | Inhibition | - | % | - | |
| CHEMBL459465 | — | IC50 | - | — | - | |
| CHEMBL459464 | — | IC50 | - | — | - | |
| CHEMBL516936 | — | IC50 | - | — | - | |
| CHEMBL459463 | — | IC50 | - | — | - | |
| CHEMBL451783 | — | IC50 | - | — | - | |
| CHEMBL453594 | — | IC50 | - | — | - |