Assay Detail
Binding
CHEMBL946423
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Inhibition of human factor 10a
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: discovery of novel, highly potent inhibitors of Factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 9.32 | 10.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL461091 | — | — | 1 | 10.68 |
| CHEMBL471550 | — | — | 1 | 10.60 |
| CHEMBL461297 | — | — | 1 | 10.46 |
| CHEMBL508428 | — | — | 1 | 10.42 |
| CHEMBL518648 | — | — | 1 | 10.38 |
| CHEMBL513062 | — | — | 1 | 10.27 |
| CHEMBL511486 | — | — | 1 | 10.26 |
| CHEMBL471565 | — | — | 1 | 10.19 |
| CHEMBL471734 | — | — | 1 | 10.13 |
| CHEMBL461090 | — | — | 1 | 9.92 |
| CHEMBL517711 | — | — | 1 | 9.85 |
| CHEMBL479925 | — | — | 1 | 9.85 |
| CHEMBL237226 | — | — | 1 | 9.82 |
| CHEMBL460884 | — | — | 1 | 9.74 |
| CHEMBL206335 | RAZAXABAN | 2.0 | 1 | 9.72 |
| CHEMBL459849 | — | — | 1 | 9.55 |
| CHEMBL218525 | — | — | 1 | 9.52 |
| CHEMBL517263 | — | — | 1 | 9.24 |
| CHEMBL221296 | — | — | 1 | 9.12 |
| CHEMBL459430 | — | — | 1 | 8.85 |
| CHEMBL452535 | — | — | 1 | 8.80 |
| CHEMBL460056 | — | — | 1 | 8.74 |
| CHEMBL508927 | — | — | 1 | 8.74 |
| CHEMBL452793 | — | — | 1 | 8.72 |
| CHEMBL511082 | — | — | 1 | 8.62 |
| CHEMBL460681 | — | — | 1 | 8.52 |
| CHEMBL507737 | — | — | 1 | 8.48 |
| CHEMBL452802 | — | — | 1 | 8.24 |
| CHEMBL510344 | — | — | 1 | 7.52 |
| CHEMBL460055 | — | — | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL461091 | — | Ki | = | 0.021 | nM | 10.68 |
| CHEMBL471550 | — | Ki | = | 0.025 | nM | 10.60 |
| CHEMBL461297 | — | Ki | = | 0.035 | nM | 10.46 |
| CHEMBL508428 | — | Ki | = | 0.038 | nM | 10.42 |
| CHEMBL518648 | — | Ki | = | 0.042 | nM | 10.38 |
| CHEMBL513062 | — | Ki | = | 0.054 | nM | 10.27 |
| CHEMBL511486 | — | Ki | = | 0.055 | nM | 10.26 |
| CHEMBL471565 | — | Ki | = | 0.064 | nM | 10.19 |
| CHEMBL471734 | — | Ki | = | 0.074 | nM | 10.13 |
| CHEMBL461090 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL517711 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL479925 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL237226 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL460884 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL206335 | RAZAXABAN | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL459849 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL218525 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL517263 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL221296 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL459430 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL452535 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL460056 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL508927 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL452793 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL511082 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL460681 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL507737 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL452802 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL510344 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL460055 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL459854 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL452524 | — | Ki | < | 0.02 | nM | - |