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Assay Detail

CHEMBL946607

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]estradiol from human recombinant ERalpha
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Estrogen receptor (CHEMBL206)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis.
Calderón AI, Terreaux C, Schenk K, Pattison P, Burdette JE, Pezzuto JM, Gupta MP, Hostettmann K.
J Nat Prod (2002) 65 : 1749 -1753
PubMed 12502307 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 5.43 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL44 GENISTEIN 2.0 1 6.52
CHEMBL512579 1 4.99
CHEMBL8145 DAIDZEIN 2.0 1 4.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL44 GENISTEIN IC50 = 300.0 nM 6.52
CHEMBL512579 IC50 = 10200.0 nM 4.99
CHEMBL8145 DAIDZEIN IC50 = 17000.0 nM 4.77