Assay Detail
Binding
CHEMBL946775
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Inhibition of p38alpha
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.40 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453438 | — | — | 1 | 8.05 |
| CHEMBL506862 | — | — | 1 | 6.89 |
| CHEMBL507714 | — | — | 1 | 6.36 |
| CHEMBL448929 | — | — | 1 | 5.75 |
| CHEMBL466397 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453438 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL506862 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL507714 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL448929 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL466397 | — | IC50 | = | 11000.0 | nM | 4.96 |