Assay Detail
Binding
CHEMBL946889
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Inhibition of human iNOS expressed in human DLD1 cells after 1 hr
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a series of aminopiperidines as novel iNOS inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.47 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428248 | — | — | 1 | 7.50 |
| CHEMBL272708 | — | — | 1 | 7.05 |
| CHEMBL403952 | — | — | 1 | 7.00 |
| CHEMBL256378 | — | — | 1 | 6.89 |
| CHEMBL256618 | — | — | 1 | 6.80 |
| CHEMBL447183 | — | — | 1 | 6.77 |
| CHEMBL271248 | — | — | 1 | 6.75 |
| CHEMBL436643 | — | — | 1 | 6.68 |
| CHEMBL114551 | GW-274150 | 2.0 | 1 | 6.66 |
| CHEMBL256620 | — | — | 1 | 6.60 |
| CHEMBL255599 | — | — | 1 | 6.58 |
| CHEMBL257007 | — | — | 1 | 6.57 |
| CHEMBL7889 | L-NIL | — | 1 | 6.55 |
| CHEMBL256249 | — | — | 1 | 6.54 |
| CHEMBL271246 | — | — | 1 | 6.54 |
| CHEMBL428069 | — | — | 1 | 6.52 |
| CHEMBL256415 | — | — | 1 | 6.48 |
| CHEMBL272697 | — | — | 1 | 6.48 |
| CHEMBL257008 | — | — | 1 | 6.47 |
| CHEMBL258310 | — | — | 1 | 6.43 |
| CHEMBL402217 | — | — | 1 | 6.41 |
| CHEMBL402425 | — | — | 1 | 6.40 |
| CHEMBL256069 | — | — | 1 | 6.38 |
| CHEMBL256402 | — | — | 1 | 6.33 |
| CHEMBL256376 | — | — | 1 | 6.24 |
| CHEMBL271247 | — | — | 1 | 6.18 |
| CHEMBL271038 | — | — | 1 | 6.18 |
| CHEMBL272271 | — | — | 1 | 6.17 |
| CHEMBL258348 | — | — | 1 | 6.16 |
| CHEMBL256414 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428248 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL272708 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL403952 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL256378 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL256618 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL447183 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL271248 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL436643 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL114551 | GW-274150 | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL256620 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL255599 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL257007 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL7889 | L-NIL | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL256249 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL271246 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL428069 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL256415 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL272697 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL257008 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL258310 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL402217 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL402425 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL256069 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL256402 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL256376 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL271247 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL271038 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL272271 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL258348 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL256414 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL402731 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL255124 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL258347 | — | IC50 | = | 5100.0 | nM | 5.29 |