Assay Detail
Binding
CHEMBL946893
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Inhibition of cytokine-induced iNOS activity in human DLD1 cells after 24 hrs
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a series of aminopiperidines as novel iNOS inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.71 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447183 | — | — | 1 | 6.68 |
| CHEMBL256378 | — | — | 1 | 6.55 |
| CHEMBL256414 | — | — | 1 | 6.50 |
| CHEMBL428248 | — | — | 1 | 6.42 |
| CHEMBL256415 | — | — | 1 | 6.24 |
| CHEMBL403952 | — | — | 1 | 6.24 |
| CHEMBL402217 | — | — | 1 | 6.24 |
| CHEMBL256402 | — | — | 1 | 6.18 |
| CHEMBL272708 | — | — | 1 | 5.96 |
| CHEMBL271246 | — | — | 1 | 5.92 |
| CHEMBL256618 | — | — | 1 | 5.85 |
| CHEMBL255599 | — | — | 1 | 5.82 |
| CHEMBL402425 | — | — | 1 | 5.50 |
| CHEMBL428069 | — | — | 1 | 5.48 |
| CHEMBL257007 | — | — | 1 | 5.46 |
| CHEMBL256620 | — | — | 1 | 5.46 |
| CHEMBL436643 | — | — | 1 | 5.43 |
| CHEMBL256249 | — | — | 1 | 5.43 |
| CHEMBL257008 | — | — | 1 | 5.42 |
| CHEMBL271248 | — | — | 1 | 5.36 |
| CHEMBL272271 | — | — | 1 | 5.36 |
| CHEMBL258310 | — | — | 1 | 5.35 |
| CHEMBL256376 | — | — | 1 | 5.30 |
| CHEMBL272697 | — | — | 1 | 5.23 |
| CHEMBL255124 | — | — | 1 | 5.17 |
| CHEMBL271247 | — | — | 1 | 5.10 |
| CHEMBL7889 | L-NIL | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447183 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL256378 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL256414 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL428248 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL256415 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL403952 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL402217 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL256402 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL272708 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL271246 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL256618 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL255599 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL402425 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL428069 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL257007 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL256620 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL436643 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL256249 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL257008 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL271248 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL272271 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL258310 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL256376 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL272697 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL255124 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL271247 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL7889 | L-NIL | IC50 | = | 31000.0 | nM | 4.51 |