Assay Detail
Binding
CHEMBL946967
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Inhibition of HDAC3
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Histone deacetylase inhibitors: from bench to clinic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.19 | 8.43 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403323 | — | — | 1 | 8.43 |
| CHEMBL272401 | — | — | 1 | 7.85 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.43 |
| CHEMBL402363 | AZUMAMIDE E | — | 1 | 7.10 |
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | 6.21 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.13 |
| CHEMBL271102 | — | — | 1 | - |
| CHEMBL406800 | — | — | 1 | - |
| CHEMBL235842 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403323 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL272401 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL402363 | AZUMAMIDE E | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL272980 | MOCETINOSTAT | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL271102 | — | Activity | - | — | - | |
| CHEMBL406800 | — | Activity | - | — | - | |
| CHEMBL235842 | — | IC50 | > | 20000.0 | nM | - |