Assay Detail
Functional
CHEMBL946986
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Inhibition of human HCT116 cells
31
Total Activities
30
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Histone deacetylase inhibitors: from bench to clinic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.98 | 7.16 |
| EC50 | 2 | 5.88 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407849 | — | — | 1 | 7.16 |
| CHEMBL269908 | — | — | 1 | 7.00 |
| CHEMBL272841 | — | — | 1 | 7.00 |
| CHEMBL258813 | — | — | 1 | 6.70 |
| CHEMBL270097 | — | — | 1 | 6.52 |
| CHEMBL254110 | — | — | 1 | 6.50 |
| CHEMBL211625 | — | — | 1 | 6.40 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.30 |
| CHEMBL209729 | — | — | 1 | 6.30 |
| CHEMBL98 | VORINOSTAT | 4.0 | 2 | 6.24 |
| CHEMBL384503 | — | — | 1 | 6.22 |
| CHEMBL241337 | — | — | 1 | 6.22 |
| CHEMBL272401 | — | — | 1 | 6.17 |
| CHEMBL379516 | — | — | 1 | 6.10 |
| CHEMBL272052 | — | — | 1 | 6.10 |
| CHEMBL272240 | — | — | 1 | 6.10 |
| CHEMBL407420 | — | — | 1 | 6.10 |
| CHEMBL260530 | — | — | 1 | 6.05 |
| CHEMBL375409 | — | — | 1 | 6.00 |
| CHEMBL378942 | — | — | 1 | 5.70 |
| CHEMBL379635 | — | — | 1 | 5.70 |
| CHEMBL214271 | — | — | 1 | 5.52 |
| CHEMBL211926 | — | — | 1 | 5.52 |
| CHEMBL368036 | — | — | 1 | 5.52 |
| CHEMBL260957 | — | — | 1 | 5.30 |
| CHEMBL260738 | — | — | 1 | 5.24 |
| CHEMBL260740 | — | — | 1 | 5.16 |
| CHEMBL209762 | — | — | 1 | 4.92 |
| CHEMBL260958 | — | — | 1 | 4.92 |
| CHEMBL211320 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407849 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL269908 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL272841 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL258813 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL270097 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL254110 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL211625 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL209729 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL98 | VORINOSTAT | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL384503 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL241337 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL272401 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL272240 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL272052 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL379516 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL407420 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL260530 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL375409 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL378942 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL379635 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL214271 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL211926 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL368036 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL260957 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL260738 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL260740 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL209762 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL260958 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL211320 | — | IC50 | = | 37000.0 | nM | 4.43 |