Assay Detail
Binding
CHEMBL947052
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Inhibition of cathepsin L
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.48 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259450 | — | — | 1 | 7.25 |
| CHEMBL2305755 | — | — | 1 | 6.89 |
| CHEMBL272325 | — | — | 1 | 6.88 |
| CHEMBL2305752 | — | — | 1 | 6.80 |
| CHEMBL558044 | — | — | 1 | 6.77 |
| CHEMBL2305704 | — | — | 1 | 6.52 |
| CHEMBL559173 | — | — | 1 | 6.29 |
| CHEMBL258148 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259450 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2305755 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL272325 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL2305752 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL558044 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2305704 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL559173 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL258148 | — | IC50 | = | 34000.0 | nM | 4.47 |