Assay Detail
Binding
CHEMBL947715
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Inhibition of rat squalene epoxidase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.16 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349197 | THEASINENSIN A | — | 1 | 6.89 |
| CHEMBL39504 | — | — | 1 | 6.27 |
| CHEMBL447974 | — | — | 1 | 6.20 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 6.16 |
| CHEMBL457687 | TRISNORSQUALENE DIFLUOROMETHYLIDENE | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349197 | THEASINENSIN A | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL39504 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL447974 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL457687 | TRISNORSQUALENE DIFLUOROMETHYLIDENE | IC50 | = | 5400.0 | nM | 5.27 |