Assay Detail
Binding
CHEMBL947923
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC3
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.12 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405072 | — | — | 1 | 5.55 |
| CHEMBL235842 | — | — | 1 | 5.00 |
| CHEMBL271949 | — | — | 1 | 4.96 |
| CHEMBL271741 | — | — | 1 | 4.96 |
| CHEMBL269935 | — | — | 1 | - |
| CHEMBL437029 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405072 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL235842 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL271949 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL271741 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL269935 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL437029 | — | IC50 | > | 50000.0 | nM | - |