Assay Detail
Binding
CHEMBL948035
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Inhibition of Akt1 by cell-based IPKA assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.52 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258696 | — | — | 1 | 6.60 |
| CHEMBL258844 | — | — | 1 | 6.52 |
| CHEMBL270444 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258696 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL258844 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL270444 | — | IC50 | = | 368.0 | nM | 6.43 |