Assay Detail
Binding
CHEMBL948042
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Effect on VDR transcriptional activity in human osteosarcoma cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(2S,2'R)-analogue of LG190178 is a major active isomer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 9.26 | 10.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 10.97 |
| CHEMBL272304 | — | — | 1 | 10.40 |
| CHEMBL403885 | — | — | 1 | 8.78 |
| CHEMBL403670 | — | — | 1 | 8.33 |
| CHEMBL272502 | — | — | 1 | 7.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | EC50 | = | 0.0106 | nM | 10.97 |
| CHEMBL272304 | — | EC50 | = | 0.0396 | nM | 10.40 |
| CHEMBL403885 | — | EC50 | = | 1.66 | nM | 8.78 |
| CHEMBL403670 | — | EC50 | = | 4.68 | nM | 8.33 |
| CHEMBL272502 | — | EC50 | = | 15.6 | nM | 7.81 |