Assay Detail
Binding
CHEMBL948317
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of steroid sulfatase-mediated conversion of [3H]E1S to E1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.99 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190628 | — | — | 1 | 7.80 |
| CHEMBL218382 | — | — | 1 | 7.41 |
| CHEMBL408967 | — | — | 1 | 6.89 |
| CHEMBL407952 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190628 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL218382 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL408967 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL407952 | — | IC50 | = | 1400.0 | nM | 5.85 |