Assay Detail
Functional
CHEMBL948323
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Antiproliferative activity against mouse L1210 cells
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.32 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.55 |
| CHEMBL364123 | — | — | 1 | 8.46 |
| CHEMBL272460 | — | — | 1 | 7.82 |
| CHEMBL227027 | — | — | 1 | 7.48 |
| CHEMBL271388 | — | — | 1 | 7.16 |
| CHEMBL271171 | — | — | 1 | 6.01 |
| CHEMBL272459 | — | — | 1 | 5.96 |
| CHEMBL410703 | — | — | 1 | 5.75 |
| CHEMBL270096 | — | — | 1 | 5.72 |
| CHEMBL270289 | — | — | 1 | 5.72 |
| CHEMBL406682 | — | — | 1 | 5.46 |
| CHEMBL270694 | — | — | 1 | 5.38 |
| CHEMBL409539 | — | — | 1 | 5.27 |
| CHEMBL270309 | — | — | 1 | 5.09 |
| CHEMBL260105 | — | — | 1 | 5.01 |
| CHEMBL407488 | — | — | 1 | - |
| CHEMBL410505 | — | — | 1 | - |
| CHEMBL270074 | — | — | 1 | - |
| CHEMBL270073 | — | — | 1 | - |
| CHEMBL270693 | — | — | 1 | - |
| CHEMBL270310 | — | — | 1 | - |
| CHEMBL260106 | — | — | 1 | - |
| CHEMBL270778 | — | — | 1 | - |
| CHEMBL410495 | — | — | 1 | - |
| CHEMBL270779 | — | — | 1 | - |
| CHEMBL430047 | — | — | 1 | - |
| CHEMBL188546 | — | — | 1 | - |
| CHEMBL272408 | — | — | 1 | - |
| CHEMBL407091 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL364123 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL272460 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL227027 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL271388 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL271171 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL272459 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL410703 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL270096 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL270289 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL406682 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL270694 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL409539 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL270309 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL260105 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL407488 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL410505 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL270074 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL270073 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL270693 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL270310 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL260106 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL270778 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL410495 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL270779 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL430047 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188546 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL272408 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL407091 | — | IC50 | > | 10000.0 | nM | - |