Compound Detail

CHEMBL270096

Enter ChEMBL ID:

Free Research Context This compound will appear in recent viewed items on the research home for this browser.

COc1cc(C(=O)c2c(N)c3cc(C)ccc3n2C)cc(OC)c1OC

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL270096
Phase	Preclinical
Structure Type	MOL
InChI Key	DXORSGBFMKVPTQ-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

354.4

MW (Da)

3.33

ALogP

HBA

HBD

75.7

PSA (Å²)

0.71

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

IC50 5 meas. best 5.8

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
FM3A CHEMBL614297	IC50	5.8	5.8	1600.0	1
CCRF-CEM CHEMBL382	IC50	5.77	5.77	1700.0	1
NON-PROTEIN TARGET CHEMBL3879801	IC50	5.77	5.77	1700.0	1
L1210 CHEMBL386	IC50	5.72	5.72	1900.0	1
Unchecked CHEMBL612545	IC50	5.0	5.0	10000.0	1

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
FM3A	IC50	=	1600.0	nM	5.8	Antiproliferative activity against mouse FM3A cells	18260616
NON-PROTEIN TARGET	IC50	=	1700.0	nM	5.77	Antiproliferative activity against human Molt4/C8 cells	18260616
CCRF-CEM	IC50	=	1700.0	nM	5.77	Antiproliferative activity against human CEM cells	18260616
L1210	IC50	=	1900.0	nM	5.72	Antiproliferative activity against mouse L1210 cells	18260616
Unchecked	IC50	=	10000.0	nM	5.0	Inhibition of bovine tubulin polymerization after 20 mins	18260616

PubMed	DOI	Target Context	# Activities
18260616	10.1021/jm7011547	Unchecked	2
18260616	10.1021/jm7011547	L1210	1
18260616	10.1021/jm7011547	NON-PROTEIN TARGET	1
18260616	10.1021/jm7011547	CCRF-CEM	1
18260616	10.1021/jm7011547	FM3A	1

Data from ChEMBL 36 via Core Engine