Assay Detail
Binding
CHEMBL949274
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Inhibition of bovine tubulin polymerization after 20 mins
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.30 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.92 |
| CHEMBL272460 | — | — | 1 | 5.85 |
| CHEMBL227027 | — | — | 1 | 5.68 |
| CHEMBL364123 | — | — | 1 | 5.54 |
| CHEMBL271388 | — | — | 1 | 5.34 |
| CHEMBL270289 | — | — | 1 | 5.19 |
| CHEMBL272459 | — | — | 1 | 5.15 |
| CHEMBL410703 | — | — | 1 | 5.08 |
| CHEMBL270096 | — | — | 1 | 5.00 |
| CHEMBL270694 | — | — | 1 | 4.82 |
| CHEMBL409539 | — | — | 1 | 4.75 |
| CHEMBL271171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL272460 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL227027 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL364123 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL271388 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL270289 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL272459 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL410703 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL270096 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL270694 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL409539 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL271171 | — | IC50 | > | 40000.0 | nM | - |