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Assay Detail

CHEMBL948337

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV2 ROD in CEM/0 cells assessed as inhibition of virus-induced cytopathogenicity
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 2
Cell Type CEM/0
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 2 (CHEMBL380)
Type ORGANISM
Organism Human immunodeficiency virus 2

Publication

Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleoside 3'-disulfides.
Gerland B, Désiré J, Balzarini J, Décout JL.
Bioorg Med Chem (2008) 16 : 6824 -6831
PubMed 18556209 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 17 4.86 5.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL488038 1 5.35
CHEMBL520901 1 5.19
CHEMBL469886 1 5.14
CHEMBL450901 1 4.92
CHEMBL470689 1 4.85
CHEMBL504460 1 4.85
CHEMBL519747 1 4.82
CHEMBL470688 1 4.82
CHEMBL469885 1 4.76
CHEMBL487410 1 4.56
CHEMBL487436 1 4.19
CHEMBL512684 1 -
CHEMBL511619 1 -
CHEMBL470294 1 -
CHEMBL512321 1 -
CHEMBL503943 1 -
CHEMBL470293 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL488038 EC50 = 4500.0 nM 5.35
CHEMBL520901 EC50 = 6500.0 nM 5.19
CHEMBL469886 EC50 = 7300.0 nM 5.14
CHEMBL450901 EC50 = 12000.0 nM 4.92
CHEMBL470689 EC50 = 14000.0 nM 4.85
CHEMBL504460 EC50 = 14000.0 nM 4.85
CHEMBL519747 EC50 = 15000.0 nM 4.82
CHEMBL470688 EC50 = 15000.0 nM 4.82
CHEMBL469885 EC50 = 17500.0 nM 4.76
CHEMBL487410 EC50 = 27500.0 nM 4.56
CHEMBL487436 EC50 = 65000.0 nM 4.19
CHEMBL512684 EC50 > 10000.0 nM -
CHEMBL511619 EC50 > 10000.0 nM -
CHEMBL470294 EC50 >= 50000.0 nM -
CHEMBL512321 EC50 >= 250000.0 nM -
CHEMBL503943 EC50 >= 50000.0 nM -
CHEMBL470293 EC50 > 250000.0 nM -