Assay Detail
Functional
CHEMBL948338
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV2 ROD in TK1 deficient human CEM cells assessed as inhibition of virus-induced cytopathogenicity
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleoside 3'-disulfides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 4.50 | 4.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469885 | — | — | 1 | 4.65 |
| CHEMBL504460 | — | — | 1 | 4.35 |
| CHEMBL450901 | — | — | 1 | - |
| CHEMBL488038 | — | — | 1 | - |
| CHEMBL512684 | — | — | 1 | - |
| CHEMBL470688 | — | — | 1 | - |
| CHEMBL520901 | — | — | 1 | - |
| CHEMBL519747 | — | — | 1 | - |
| CHEMBL487410 | — | — | 1 | - |
| CHEMBL470689 | — | — | 1 | - |
| CHEMBL469886 | — | — | 1 | - |
| CHEMBL511619 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469885 | — | EC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL504460 | — | EC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL450901 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL488038 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL512684 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL470688 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL520901 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL519747 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL487410 | — | EC50 | = | 150000.0 | nM | - |
| CHEMBL470689 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL469886 | — | EC50 | >= | 10000.0 | nM | - |
| CHEMBL511619 | — | EC50 | > | 10000.0 | nM | - |