Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL948339

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human Molt4/C8
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MOLT-4
Confidence 1 — Organism
Curated By Autocuration

Publication

Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleoside 3'-disulfides.
Gerland B, Désiré J, Balzarini J, Décout JL.
Bioorg Med Chem (2008) 16 : 6824 -6831
PubMed 18556209 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.45 4.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL488038 1 4.58
CHEMBL520901 1 4.57
CHEMBL512684 1 4.55
CHEMBL469886 1 4.54
CHEMBL511619 1 4.51
CHEMBL470688 1 4.47
CHEMBL519747 1 4.38
CHEMBL469885 1 4.26
CHEMBL450901 1 4.18
CHEMBL487410 1 -
CHEMBL470689 1 -
CHEMBL504460 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL488038 IC50 = 26000.0 nM 4.58
CHEMBL520901 IC50 = 27000.0 nM 4.57
CHEMBL512684 IC50 = 28000.0 nM 4.55
CHEMBL469886 IC50 = 29000.0 nM 4.54
CHEMBL511619 IC50 = 31000.0 nM 4.51
CHEMBL470688 IC50 = 34000.0 nM 4.47
CHEMBL519747 IC50 = 42000.0 nM 4.38
CHEMBL469885 IC50 = 55000.0 nM 4.26
CHEMBL450901 IC50 = 66000.0 nM 4.18
CHEMBL487410 IC50 = 163000.0 nM -
CHEMBL470689 IC50 = 128000.0 nM -
CHEMBL504460 IC50 = 149000.0 nM -