Assay Detail
Binding
CHEMBL948371
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Displacement of [3H]PK11195 from peripheral benzodiazepine receptor in rat kidney membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Kidney |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of substituted [18F]imidazo[1,2-a]pyridines and [18F]pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.33 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469681 | — | — | 1 | 8.43 |
| CHEMBL469682 | — | — | 1 | 8.39 |
| CHEMBL512306 | DPA-714 | 2.0 | 1 | 8.25 |
| CHEMBL469680 | — | — | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469681 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL469682 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL512306 | DPA-714 | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL469680 | — | Ki | = | 5.8 | nM | 8.24 |